There are many software choices out there. I tested several before I settled in with Innerspace/ISBoxer. I would rate it as medium in difficulty to configure. I would have said closer to hard if Ualaa hadnt written a guide that goes so deep into functionality. If you are good with logic or programming, its not too difficult to learn.

My suggestion is always to run the wizard and play for a few levels with just the basics and Jamba. Once questing gets annoying, read the section on click to move and interact with target. Once you are comfy, start adding your own key maps. Once that is easy, then you can start with click regions or "next click" functionality. Then move on to Action Target Groups. It offers the most granular control of each of your characters of any of the products I have tried, it just has a learning curve.

If you have issues, they have an IRC channel, and Lax responds quickly to help people.