At this point I almost find it difficult to work w/o 4 monitors. Love the real estate.
You can definitely still use the PiP swap but because you'd be swapping from a monitor using the secondary GPU to a monitor using the primary GPU you get the performance hit. Again, I'd love to test this on a motherboard with two x16 slots. But, I have a feeling I'll be buying a 30" for my main screen soon enough and I can just jam all 5 instances onto that main screen nice and easily.
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