My general rule is:
cooldown less than 3 seconds? use reset=target/combat
cooldown less than 6 seconds? use reset=target/combat/6
cooldown more than 6 seconds? use reset=combat
I make the final decision based on other spells in the sequence
Note that I don't use clicksequences or single button spamming either and often run mixed groups - so I customise the macros based on group makeup, target type, etc.
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