Although it would be insanely convenient, I basically use the quests as a a lazy man's guide on where to go. In the meantime I follow those quests for about 50% and use my own 'judgement' for the other half. Just look around, especially with the new minimap enhancements it's easy to spot questgives. Read the discription, if it's some elite quest you pick it up instead of skipping it, if it's a collection quests which requires anything more than 5-6 drops you skip it. Ofcourse 'pickup' quests are usually quite doable, the respawnrates of most are quite decent to do them quickly.
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