Non-heroic instances can be reset 5 times per hour.
Given the initial run, which does not require a reset.

That is 6 runs in 60 minutes, or a run every 10 minutes.
However, after the first hour (6 runs, 5 resets), 12 minutes becomes the key (the point where you can run back to back without waiting for a reset).

000 - 010... Initial Run.
010 - 020... Reset #1
020 - 030... Reset #2
030 - 040... Reset #3
040 - 050... Reset #4
050 - 060... Reset #5

060 - 070... Reset #6
070 - 080... Reset #7
080 - 090... Reset #8
090 - 100... Reset #9
100 - 110... Reset #10
110 - 120... Locked Out.

Once you get your pulls down, your slave movement etc.
You can slow yourself down to 12 minutes a run, by looting.

One trick I like is to use the Master Looter system.
Put the loot on Master Looter.
Have your booster/active toon be the Master Looter.
Have your booster opt-out of loot.
Set the threshold to whatever color (or better), you'd like your Master Looter to have to master loot the drops.

Now, because you have opted out of loot, nothing sparkles.
Unless it has a (threshold) or better item on it, in which case the corpse sparkles.
And you'll have to right click on it, and pick who the item goes to.