Initially I went to 5 boxing because of the long wait times to find a group and at times even when there a group formed someone dropped or all the loot annoyances.
When the new lfg went live I seriously though about dropping 4 accounts but there are just so many benefits to multiboxing I never dropped my other accounts.

@ Bigfisg yer links dont work
Binding Mouse Clicks to your Keyboard
Running Concurrent /castsequences to keep the hassle out of DoT management