Yes, Lots of Macros!

I've read that some people click, but I haven't tried that yet, so I can't comment on it.

I've tried a pally / mage / lock / priest setup and its not that hard to control. Their spells align pretty well.

I have a frostbolt/shadowbolt/smite bound to my first ranged attack and a DOT setup on the 2nd.

I would start attacking w/ the paladin, and then start hitting F1, F2 for the ranged to attack.

After trying it for a while I got used to it. I was pretty effective with it after a few levels. I havn't run any high-level characters yet, but I'm excited about making it work.

Part of the fun for me was getting everything to work right