I would actually recommend the numpad mode on the naga, that is what I use and i find it extremely functional and the new razor naga software works just fine with isboxer. Also the new naga firmware allows you to rebind the keys on it to anything you want ( alt shift ctrl .. ect ect ). I currently have my instant nuke key and my focus key on the naga, as well as all 3 of my modifier keys ( alt shift ctrl ), my mount keys and my ghost wolf key, it works wonderfully. I will say the naga's ergonomics take a few hours to get used to but I've enjoyed it a lot. It's really not a bad fps mouse either, I play counter strike a good bit and find it to be pretty good there as well.

I also 2nd the opinion that Isboxer is the best boxing software out there, hands down.