The damned will keep coming (up to 3 extra in addition to the two at the top of the stairs) until the main two are dead.
So it is best to mark the main two, and kill them first. Until they are dead, you just gotta blow cooldowns and stuff to survive the rest of them. When the main two are dead, you will have unlocked the rest of the trash and can go on in whichever fashion you want.
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