Before switching to FTL, I was using the original version of the No Focus Manifesto.
Not sure what has changed in version 2, as I switched before then.

The basic idea on no focus, is to assist by target.
So each toon is targeting the active toon.
And casts at the target's target.

Which can be adapted very easily..
To your assisting the target.
Melee actually do that, and Hunters with the no-focus manifesto.

Or alternatively, just go with the full blown manifesto.
It is as strong as a focus set up, as far as what it does and where you can use it.
Plus focus is free for other things.

If you can get an FTL set up working.
That's stronger then reliance on Targeting, Focus or Leader.