Even if you have the space, I'd break each spell into its own macro.

So you end up with a master macro, which you mash.
And this calls each of your other macros in order.

Then you have one macro for each spell.
But you could have a targeting macro, quite easily; I've seen Starbuck_Jones list one in his click macros.
I'll actually put his targeting macro on Macro 1, later.

Take your druid, for example.

Master Click Macro, calling 5 macros.

Macro 3 - Insect Swarm
Macro 4 - Moonfire
Macro 5 - Wrath or Starfire or /Castrandom Wrath, Starfire

Nothing on Macro 1 or 2.
Which means you have space to include something else, if you need it.

Macro 1 (Starbuck_Jones's)
/assist focus
/target frost tomb
/target chaotic rift
/target guardian
/use 13
/use 14

You still have space to include something on macro 2 if you want.

Or if you are facing trash and just want to burn it fast...
You can pull your IS and MF macros out of those button positions.
And now your click is just doing Wrath spam.

The modular set up of click is a major strength.