If you are running multiple spells with different cooldowns, click will let you have them all in one super macro. Macaroon will let you go to 1024 characters, if you want them all in one physical macro. However, the author has quit wow and no one else has taken the project up, so its likely to break at some point and space will be an issue once more.

The ability to drag a button (macro) from spot a to spot b or whatever. Or do drag a spell into or out of position depending on what you're attacking, is the benefit when number of characters is not an issue.