Is there a way to make a button "un-clickable"

[Allestaria]

LOl I know a not so good way to do it..

Write a macro something like /castsequance reset=15 Frostbolt, fostbolt.

Miss spell the second command. It will reset in 15 seconds but the key will become useless because of the miss spelled command.
You will see the red ? until it resets.

I know I know.. poor way of taking a mistake and turn it into what you actually want without another addon to do so!

[Solon]

I feel that this would step beyond the boundaries into automation. I wouldn't use it. Neat idea to get around the spirit of the rules though.

/castsequence reset=15 Frostbolt, fostbolt

This would not provide any benefit to a spam macro at all. The 15 seconds for reset requires you to not trigger, click, or /click call the macro for 15 seconds.

[Ughmahedhurtz]

I feel that this would step beyond the boundaries into automation. I wouldn't use it. Neat idea to get around the spirit of the rules though.

This. What you're talking about would very definitely be considered an exploit by Blizzard if you could even do it.