Well, the tradeoff is that you can't glance over to make sure all 5 guys actually picked up teh quest. Jamba's notifications help a LOT with that, though. Make it as spammy as you want. You might have trouble with things like one toon getting turned around or out of range to loot something due to lag or something similar. So many little things that a glance at your alts will confirm/deny.

Get a really comfy 'puter chair and it becomes a moot point, minus the TV in the background. :P