Thank you so much for answering so quickly 
my apologies, im not clear enough with the second part of my questions (been up all night trying to figure this out lol)
Your code uses MouseIsOverWindowRect, I'd use the win position. Win position is the position of the cursor within the confine of that specific WoW window. Scrn pos is the position of the cursor within the confines of your entire monitor.
Ok, that means the starting coord for the Party Frame if its clamped to the Upper-Left most of the Window, would be x=0 y=0 ?
The first set is the top left corner of the region. The second set of numbers is the the dimensions of the "box" that grows from that point

so the end result inside a code is :
Code:
<If MouseIsOverWindowRect WoW1 0 0 227 341>
If you're trying to use mouseover healing, it should all be in one action. Basically :
1. Create a macro on your healer that says /cast [@mouseover] Some Heal
2. Put that macro on F1
3. Define your healing region properly.
4. Use the below code
Code:
<Hotkey F1><If MouseIsOverWindowRect WoW1 *YOUR REGION DEFINITIONS HERE*> <SendLabel w2> <Clickmouse Noclick> <Key F1> <RestoreMousePos>
4. Mouse over the region on your main WoW, press F1. It should automatically heal whichever toon you have your mouse over.
U have read my mind ! thank you ! 
the aboce code works like a charm
with only 1 small problem
this is the code im using :
Code:
<Hotkey F1>
<If MouseIsOverWindowRect WoW1 0 0 227 341>
<SendLabel w2>
<Clickmouse Noclick>
<Key F1>
<RestoreMousePos>
the problem :
the reading of the mouse position seems lagging ?
i dont know the best way to describe this problem im going to use 3 screenshot for the steps :
The first step was flawless, the Healer Heals the intented Party member (yay !
)

Now the second step when i move my mouse over to Party2

Now the Step 3, and im not moving my mouse at all, the Healer finally heals the Party2

From what i understand
-if im not moving my mouse at all, perhaps the problem is not on the Party Frame coordinate
-im using PitBull to Force all 5 Character into 1 Party Frame, and Sort them Alphabetically
so if im trying to heal another Party member, the mouse seems to be stuck on the last coordinate, until i press the F1 the second time, and it goes to the right coordinate
for additional info, this is my Screen looks like in cascading window, to make sure that all the party member are on the same position and sort alphabetically

And this Screen is my playing Setup, i Stacked all the window at the same position, i dont know if thats good or bad

Again Thank You So Much Khatovar, for answering my questions
and my apologies for the lousy english (indonesian)
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