A few things I did to reduce the frequency of this:

Leave melee toons on follow while I pull. The shorter the distance they have to go, the less the chance of them getting stuck in run mode.

Don't spam IWT. I know people love to spam IWT so your slaves will stick to runners, but if the mob isn't moving that much, it almost always caused my toons to go berserk. I went from spamming IWT as often as I spammed my DPS button to using it only when I needed to. It reduced my run-aways in combat to almost nothing. If I do get one running, I just tap my down arrow and interact once.

If you use Jamba, set your melee toons to auto-follow after combat. With the first two changes, most of my remaining run-aways were from my toons deciding to go for a random jog to cool down after combat.