You'll need a software for boxing.

I'll recommend IS Boxer, which you can try for 7 days free.
There is a wizard to set this up.
There are other options you can go with, such as HotKeyNet, GameCommandPro, Keyclone etc, but I like IS Boxer the most.

You can broadcast mouse clicks with IS Boxer, by creating a repeater region over your hotkeys.
IS Boxer is not the only option for mouse broadcasting, but it is a strong one.