I admit that I haven't tried all the software out there... but I have thoroughly enjoyed using Game Commander Pro (http://www.gamecommanderpro.com/).

The commands/keybindings don't have to relate to your hotbar bindings at all. And a really neat thing about it, is that GCP understands a group's "sub-roles"... tank, healer, dps. You can assign toons to each of these roles. And you can switch your healers to the dps sub-role, and visa-versa... casting different spells depending upon their role.

It offers so much more... check it out