Verify that keymaps are on, as hotkeys don't do much if they're not.

The quickest place to get help is in the IRC, which can be found here: http://www.lavishsoft.com/chat/isboxer.php

Also, if you post your configuration, that can help, as others can open it and check exactly what you have done. You can get to your configuration from the file menu in IS Boxer Toolkit. Select Copy to Clipboard, then paste it on a site like www.pastebin.com, then get the link to the config. There's an option to copy the config without the account information now.