I used to 5-box on a Mac Pro, 12gb RAM, 30" monitor, using Spaces to hide my followers. This worked okay but I tend to key-spam in instances, which caused some lag issues the Clonekeys. Login was annoying as I had to arrange windows etc., lag in Shattrath (this was last summer 08 or so) was a bitch. I switched to all-hardware and I like that better.
Current setup is 24" iMac, 27" i7 is in the mail to me supposedly. This is where I run my main/iTunes/vent/etc., graphics mostly turned up. Followers are on 4 x Mac Mini, each with a 19" monitor on a 2x2 vesa mount, graphics mostly turned down. Input is via wireless non-bluetooth keyboard, all 5 computers set to the same channel. Mouse input is via main machine and synergy. Additionally I have a 4-input KVM with keyboard and trackball, but that doesn't get used very much.
This setup works very nicely. 30fps+ on the follower boxes, 60fps on main machine, no problematic lag anywhere -- except that Dalaran is quite laggy on my main machine since 3.3, which I think has to do with one or more mods that I only have on my main (followers use a minimal mod suite) or perhaps insufficient system memory, since the slaves are unaffected. My only complaint really is Synergy won't let me mouse off the main machine if it's in full-screen, so I have to run that one windowed -- I'm used to it but would rather run full screen.
You can of course boot Macs into Windows via bootcamp, so there's never been any question for me as to which hardware to buy. You get a Mac you get the ability to run Windows for games and Mac OS for, well, everything else. Having to reboot for games is mildly irritating at times, but with WoW that isn't an issue.
I raid on my main pretty regularly (not multiboxing), and not a night goes by where at least one person doesn't DC at some point during the night due to their machine crashing. Not just WoW, but they're off vent as well for a minute or two while they reboot. This is never one of the four or five of us who play on a Mac. Anecdotal I know, but amazingly consistent.
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