Ok great. Here are the details that I have.

System as follows:-
ASUS Rampage Motherboard.
Creative X-Fi Sound card.
2 x Nvidia GTX 295 graphics cards.
12GB RAM.

Drivers as follows:-
DirectX 9c
Nvidia drivers 185.85

IS set up as follows
Each monitor runs on a separate graphics card.
The primary monitor is 1920 x 1200. (1920 x 1200 monitor).
The secondary monitor is split into four 800 x 600 screens. (1600 x 1200 monitor).

I have made no special changes to the initial IS/ISBoxer set up.
I created the characters and character set.
Set CPU cores to screens, 4 cores to primary, 1 core to each secondary.
Created Window Layout, assigned character set and character slots.

Do you need any further information?

Thanks again,
Winters