What you have to do is record a macro. Basically start a new macro, hit the record button, press and release buttons like cntl 1. Remove the delays and save it to a name. Then left click on a key and choose the macro. Then save the setting and hit apply so that the macro will get stored into the n52te internal memory. After doing all this and it still doesn't work then unplug the the connection, wait 10s, then plug it back in.

Of course this all assumes your are running the software as administrator.

The n52te is a craptastic POS that works once you figure out all the nuances. Take it back and get a g13 if you can.