I use mouseover healing {pve} with HKN. I don't know if other programs can do actual mouseover healing or if they only work with click-to-heals. But my setup works the same with 5-man and 10-man since it's mouseover {the only thing that changes is the unit frames are smaller}.

But I couldn't begin to tell you how it would fare in a place like AV. Things get too laggy, healing could become unreliable.