Thanks to both! You did completely answer my question. Obviously I need to play with it now and test it out.
Interact with target is a no-brainer, use that for questing now, but have never played with click to move.

This question might be pre-mature (I'll go play after I ask), so feel free to ignore it; but for us PvPers at heart (i.e. - mouse turners) I would think 'click to move' would be dangerous...at least for a while till I break myself of old habits