I use repeater regions with ISboxer and I have more or less replaced Vuhdo with the normal mana and health bars as I only look at vuhdo during fights for information about health....

I don't have any clue how you guys gets your melee team to run around a given target... but if you are dependent on a mouseclick to attach targets then I think you might have a hard time using repeater regions to the max as they require you to move the mouse over the toon you want to heal (depending on the mod you use).

But Vuhdo really free up alot of keys - atleast for me, and I can bind different macros for different clicks ie. Right click = Regrowth, left = click - Rejuv etc. Also Vuhdo decurse etc. if you want it to.

I try not to have alot of shift+ctrl+x keybinds as they get a bit confusing to me.... KISS as they say hehe (Keep It Simple Stupid)