My experience is the same on the prophets. My pallies had a hard time, just gotta be fast with the running away. I usually find lining up so that when he's about dead, I strafe-run everyone off to one side which is faster than trying to /follow your alts out of the way. 5x consecration helped kill 'em off that last little bit, so your experience may be slightly different.

The last boss (Ikiss) is definitely painful, though it's like a 5 second cast time. Fight him right next to a pillar and then just run around the corner. I rarely get hit by him anymore.

The tinkerers were definitely a problem, though some careful CC (which you'll have plenty of once you get Hex on the shams) worked pretty well for me. Stun 'em AFTER you run into melee range and they should die before the judgement wears off. Granted, I had 5 judgement stuns so I had a little less trouble with multiple tinkerers.

2nd boss in Mechanar was definitely a problem and for me was more about luck with the elemental AoE than anything else.