The virtual config files are a huge as far as system performance goes.
I crank everything down to low, on the slaves.
On the main, I like view distance and spell effects up some.
That really helps.

Everything is rendered at full size, even if its then scaled down for a small window.
Inside of cities like Dalaran, looking at the ground while zoomed in (on the slaves) helps a lot too.




Not sure what you mean by Keymaps.
But if you elaborate, we can help ya.