What OS are you running?
I say this because I run 5 copies of wow off a single IS profile and have zero framerate changes when I cross video cards. This was the case in Vista as long as I crossed HEADS of a single video card, but crossing p hysical cards caused huge performance hits.
ISBoxer isn't necessary for this with Windows 7 and NVidia cards. I don't know if this works for ATI cards because I haven't dropped money on an ATI card in 6 years.
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