At one point, I could keybind mouse clicks in wow, and keyclone would broadcast them fine. I had one for assist the main and another for interact with target. They stopped working at one point, and that's when I switched to a mouse button is a key combination, which worked fine.

I used the Set Point software for my Logitech mouse (G5), and had various mouse clicks send keystroke combinations. This worked fine with Keyclone.