hmm I was under the impression that when you changed maps it changed keybindings.

edit: wish you would have mentioned this when I was in IRC chat the other day, save me 3 hours of logging in and out trying different things =(
I'm not sure how what you just said relates to what I said, which is probably along the same lines as why I didn't mention this in IRC. Had I realized you were trying to make WoW Macro Actions with the Key Combination set to an Action Bar button, I might have told you to hit the ? next to Key Combination, which explains that you can't use Action Bar buttons as the Key Combination.

So back to this...
hmm I was under the impression that when you changed maps it changed keybindings.
When you change Key Maps, it is not making any changes in WoW. All WoW Macro Actions for any given Character while a are stored as WoW Macros, and bound to keys. This happens when you log into your character, when the ISBoxer Addon loads. The WoW bindings will stay that way until you log out. WoW will not let ISBoxer override the key bindings used for your Action Bars, so in actuality, a WoW Macro Action with the Key Combination set to 2 is precisely the same as a Keystroke Action with the Key Combination set to 2. It can't change what 2 does, but it's still going to press it.