I just started multiboxing, so like yourself I am new. I found that Innerspace works very well for what I need to do. I have a classic pally and 4x elemental shamans. I drive with the paladin and leave the shammies on auto follow. Before a fight starts (in a dungeon like SM) I have the shammies break auto follow and drop totems, then I have the pally pull and tank. If I need to heal, I click on my VuhDo window from my tanks screen to heal whoever. With mouse broadcasting regions (via Innerspace) I can heal from any window of WoW. I think the hardest thing to do is setup your macros, but that is easy enough to setup. I spent a good 2 hours or so setting up the macros and testing them out on training dummies. But once you get that setup, it's smooth sailing. I'd say start with something really simple, and then add in more complexity as the need arrives.