With click castsequences, you can macro in all of your dps moves and cooldowns.

However, you're not able to cast a cooldown on demand, at least not for a lot of classes at once.
Too many things happening.

So, we basically combine all of the buffs, focus fire on a single target etc.
And a strong PvE dps sequence.
But don't have the ability to click this ability in response to that move etc.
If you can dictate play, you can probably anticipate what will happen and have your macro's set for their responses.
If play is incredibly variable, the macro's become weaker.