With Keyclone, our only option was the white/black lists.

Keymaps are a much stronger option.
They get you a ton more flexibility in what you can accomplish.
You can have a lot of things happen on one step.
And include as many steps as you like (different results on successive presses of the same key).

I'd strongly recommend going with Keymaps.
And not using the white/black lists with Inner Space.
If you like, you can organize your key maps into different groups, you're not limited to just General, Control and FTL.
Then you can have a Keymap like the Control Keymap to turn on or off an entire set of keymaps.
It gives you a lot of flexibility.

I use the F key, to have all of my slaves assist the hot toon and get her target.
So like you, with Keymaps on, I cannot send the F key in any chat.
When chatting its easiest to disable keymaps and have repeater off.
Or keymaps off and repeater on, when doing passwords.