I've been boxing melee toons since late 2007. I find the new 'interact with target' function very helpful. It does the job of orienting the toons in the right direction for melee purposes. I now no longer have to turn my toons manually, or force my toons to run/fight in a straight line.
However, because of the glitch with 'click to move' (e.g. your toons running off) binding the forward and backward keys may still be necessary to prevent it. e.g. I tap the forward/backward keys once as my toons are close to the mob as it stops the running, which should prevent the glitch.
For PvE purposes it might help if you don't spam the 'interact with target' key (unless it's necessary); you shouldn't need to anyway since most NPCs don't move as fast as players do.
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