I would say post the macro, is the example that you have five rogues and they are all interact with target and then hitting a another button for a /assist /castsequenc macor?

If your using some method of pushing two key commands ala, CTRL-I for interact with target and then a grind macro like Backspace with a programmed wait from one key press. These are going to queue up in some multiplexers. If you cannot avoid doing this, you need someway of dumping the queue in the multiplexer. Likely this is toggling the multiplexer off and on.