Um some suggestions.

Macro issues -> Get Macaroon. It makes creating and changing macros amazingly fast and organized. Also, patch day comes... nothings broken.
FTL? -> I'm using ingame FTL (not the ISboxer pre built FTL), so all of my ctrl / shift / alt modifiers are used as well. No biggie. There are plenty of keys to choose from, just gotta make intelligent choices.
PIP? -> Yes ISboxer/Innerspace is hands down the best. Super fast, I'm still getting used to using PIP again because I abandoned it with keyclone.
Sluggish -> A lot of people say IS seems faster on overall response. I've seen a small improvement, but not the magical framerate boost people were talking about... mine is slightly better at best. Key response seems great though. I think any speed gains are probably more related to decreased HD seek time from sharing 1 directory.