Stick with Core i7, 12GB RAM, HD 5870 (especially for 3-monitor support in current version), and an SSD. You can cut corners with everything else to save cash, but with unknown system demands for Cataclysm next year, I wouldn't risk having anything less than the above items at a minimum. The performance hit when BC came out was steep, and again significant when WotLK was released. I'd expect Cataclysm to be even more detailed.
I'm holding out for specs on the 5870 2GB, 5870X2, and 5870 SIX/Eyefinity before upgrading the videocard - still on an 8800GTX with watercooled Core i7 EE965, 12GB RAM, 2x300GB Velociraptors in RAID 0, 60GB SSD, etc.
As it currently stands, the 5870 1GB & 2GB support 3 displays as long as at least 1 has Display Port (24" Dell 2408 Ultrasharps do) The 5870 SIX appears to require 6x Display Port monitors. The 5870X2 looks like it has 2x DVI and 1x min-Display Port.... which has me leaning toward the 5870 2GB model for my 3x 24" Dell Ultrasharps if it is released soon, or possibly the 5870X2 if I feel it is right around the corner when the 2GB 5870 comes out.
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