I started out with Keyclone, as it's a great product that is easy to setup and gives you results "straight off the bat". However when I realised that I would be needing simultanious AOE / windows clicks from one click, keyclone did the job but was not quite ant the ease of use that i needed. I therefore now use Hotkeynet and have never looked back.
I would still however recommend Keyclone for people starting out that have no knowledge of basic scripting. HKN can be a bit daunting at first unless you spend a good deal of time reading up on what it can do, but believe me the results are worth it.