Poor example as you wouldnt want to refresh MF and IS that quickly anyway but you are right in this case as MF and IS are instant cast but as soon as you add another casted spell to the end of that /castsequence you are losing dps.
A normal castsequence macro has to wait for the server to confirm that a spell has been successfully cast before moving onto the next one. This is a non issue if all the spells are instant as the confirmation happens within the GCD. For casted spells it is a huge dps loss because you can not queue up the next spell when the client is ready - anyone remember when you had to use /stopcasting macros and quartz to maximise dps? Well /castsequence still has this issue but /cast does not. ie
/castsequence Lightning Bolt, Lightning Bolt
is less dps than
/cast Lightning Bolt
/Click or more specifically /castsequence with multiple commas do not suffer from this issue as the commas are used purely for timing client side
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