About the FTL and following. I haven't set up multiple pc's yet but I have an idea. You should setup the whole team on the master pc. I believe there is selection dropdown list on each character as to which pc to launch on. When you push settings it will send the data to Innerspace on both pc's. I think you setup each pc with Isboxer and that will give the results you have listed. When you assist and follow it is doing each pc's characters as if they are the only ones in the group because that is the way you set it up. Wipe the Isboxer on the second machine.

For mouse repeating to click on the same spot the aspect ratios need to be the same. So 16:10 on all instances for example.

I personally use 2 monitors with one fullscreen on the right and 5 thumbnail placeholders on the left monitor. This isn't one of the wizard options but it is part of the layout section when you make your own. Remember you can make your instances layout anyway you want because you can resize and drag them anywhere on the layout setup screen.