I really don't like Clique/Grid/blah. I set up my healing to use a pass-thru region in HKN so I could use mouseover healing/curing without having to worry about targetting or slowing up on DPS. If I mouse over the group portion of my screen, I cast heals. If I'm not over that region, I'm purging and casting Riptide on my tank and Enh Shammy.

Makes things a lot easier for the transition between 5-man and 10-man, as well, since I don't have to specify 5 more units for heals and if I need to swap out someone, it has zero impact.