That's what I thought, thanks for the quick response.

So the alternative for this would to have both computers set up with a "leader" region, and when wanting to swap over to 3, 4, or 5 to just change the PiP on the second computer to focus on that computers leader region?

As a secondary question, when using Keyclone across multiple computers, does commands on the first computers keyboard activate the second computers PiP hotkeys?