I use Grid as my primary party/raid frames while both multi-boxing and single-boxing. I have the normal party unit frames disabled (I can still the unit frames of myself and my target, though).
I don't see that normal frames give me any information that I need to know, but they take up a large amount of screenspace, so why use them?
Grid shows me health/mana and all relevant debuffs, and SmartBuff tells me when people need buffs - what else do you need a unit frame for?
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