For my setup, I have basically 3 sets of keybinds.
Main = normal FPS/DOOM/Quake/etc. movement keys on the home row.
Alts ONLY = left/right/forward/back = arrow keys (not keypad)
Everybody = left/right/forward/back = keypad arrow keys; strafe left/right = keypad 7/9
It is so rare that I have to move my tank around much (Eck and certain other mobs that charge/leap/spaz aside) that I can usually drop the mouse and handle movement pretty well with just keyboard. Helps a LOT on stuff like those dark caster trash mobs at the beginning of DtK that drop the shadow pools. Gotten good enough at it that I don't usually have to heal 'em anymore after that happens.
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