my d-pad is used for forward, back and strafes left and right. thumb button is jump.
top row is 67890
middle row is 12345
bottom row is tab alt - =

for boxing, my main usually will use most of the buttons. my alts will use only 67890, sometimes -= and also alt (12345). many combinations. i dual and tri box. keeps it kinda simple. but 5-boxing might require more keys from your keyboard should you need to swtich leaders, etc. i cant use my scroll wheel on the n52. its too stiff to actually do anything. so is the big orange button. now my n52te is a bit better.