I've never made so many options in a macro I needed more than just the control key so I bound lctrl to the orange button above the dpad. then I made the upper dpad button turn left, the forward one up, the low one closest to the "15 button" turn right and the last place is back. Using it this way I have the 15 key bound to space bar, so I can move around with the mouse and DPad in concert and use the knuckle on my thumb to jump. All the other buttons are just 1 - = and numpad0 and 1. with those 14+lctrl mod on my left hand I have plenty of binding options to cover just about everything.

My 5 button mouse with it's extra little search button (a sixth button :P) bound to mount, handles the left/right clicking plus auto-run and "follow me" on the main. The middle mouse button (clicking scrollwheel) sends left click to all the alts and holding lctrl and pressing it handles the right click passing.

Anything I can't do on those 2 is handled with the F1-F12 keys, but thats pretty much just buffing/changing gear/spec type stuff.

In PvE I use the remainder of the numpad keys for specialized healing