You can create an action target group "healers" and drag your healer to it. Then when you write heal macros in Isboxer you can send the macro to the healer window instead of "all windows, all other windows" etc. It will show up on that list. You should put your targeting in the macros just like any other macro.
So you can strike those keys and that macro will fire off only on the healer (or group of healers for some folks).
Frankly I went with VuhDo because the setup was a lot easier than healbot. It has an option to order the group alphabetically. You can drag in spells from your spellbook or type in a macro name of a prewritten macro (it will recognise it)(much like healbot). Even if you only use 3 mouse buttons for heals, that is more than you currently have and you save those keyboard keys. I don't use any modifiers for healing, just the unmodified clicks. I use 5 buttons: Earth Shield, Lesser Healing wave, Riptide, Healing wave, chain heal.
Remember clicking on the isboxer region only sends the clicks to the healer window. Clicking elsewhere on your screen will be normal mouse behavior. I am at work right now or I would post a screen shot of my arrangement. It is very easy to train yourself to heal like this.
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