i use an hdtv as my sole monitor. one thing to keep in mind, unless you have an awesome video setup on your pc, youre framerates will be less than diserable running multiple clients (especially when in windowed mode). i used to run windowed, had all graphics turned down, and would still have ui lag when raiding. just a word of advice.

what owltoid said is great info too, sit a decent distance away. sittin too close to a screen that big is far too much strain on your eyes, especially for longer periods of time.