I have one (Logitech Harmony 1000) for tv / home cinema/ stereo. Very nice remote, easy to set up, excellent WAF.
I would not even know where to start if I would have to make it do the kind of thing the OP is suggesting, though.
My approach is to make a huge 22 button action bar (using Dominos) that has the same layout as my G13. I can then freely move icons/macros on this custom bar to fit my needs.
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