I agree with Fur on this one.

Castrandom lets you put several situational spells on a button, which whether part of a sequence or not, could prior to 3.2 allow you to spam the button and get the correct spell eventually without even knowing it had proc'd.

Castsequences with or without comma's are making no decisions for us. They are not casting spells we have not chosen. They are essentially pressing button 1 every 10 seconds, button 2 every 15 seconds, button 3 every 6 seconds etc. You can choose to press the buttons in that order and on that timing manually if you desire. All the macro does, is allow you to push them in the order you desire at the timing you have chosen prior to the encounter.